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TSH is a hormone produced by the pituitary gland that signals the thyroid to produce T3 and T4. It's the most sensitive and commonly used test to screen for thyroid disorders, since even small changes in thyroid function affect TSH

Free T4 measures the unbound, active form of the T4 hormone circulating in your blood. It's considered a reliable and direct indicator of thyroid gland activity and is commonly used to diagnose and monitor thyroid disorders.